Six people – four adults and two children – died in a crash between Wakefield and Barnsley.
The collision, which involved a car and a motorbike, happened on Sunday afternoon on the A61 Barnsley Road.
A motorcyclist and a pillion passenger, a man and a woman, were confirmed dead at the scene.
A man, a woman and two children, a boy and a girl, who were traveling in the car, were also confirmed dead at the scene.
Emergency services received reports of the crash involving a Ford Focus car and a motorcycle just before 4pm on Sunday.
The road has been closed between Shaw Lane and Warren Lane and is likely to remain closed for some time as the investigation continues, West Yorkshire Police said.
Superintendent Alan Travis, of Wakefield District Police, said: “This is an absolutely tragic incident which has resulted in the loss of six lives.
“Our thoughts are with the families of those who died, who we are working with to provide support at this time.”
West Yorkshire Police have appealed for anyone who saw the crash to get in touch.
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